pentobarbital will lessen the extent or influence of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; prevent use in patients that are chronically utilizing a solid CYP3A4 inducerIn a long time past, barbiturates have been a typic